کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2068707 | 1078341 | 2014 | 9 صفحه PDF | دانلود رایگان |
• Mitochondrial Editing Factor 26 is a DYW-PPR protein involved in editing at 2 sites.
• The two sites cox3-311 and nad4-166 share similar cis-elements.
• Both sites conform to the amino acid code for RNA recognition by PPR proteins.
• In a mef26 knockout mutant, RNA editing is completely lost only at site cox3-311.
• MEF26 orthologs are not present in all plant species able to edit these sites.
In angiosperms most members of the large nuclear-encoded family of pentatricopeptide repeat (PPR) proteins are predicted to play relevant roles in the maturation of organellar RNAs. Here we report the novel Mitochondrial Editing Factor 26, a DYW-PPR protein involved in RNA editing at two sites. While at one site, cox3-311, editing is abolished in the absence of MEF26, the other site, nad4-166, is still partially edited. These sites share similar cis-elements and application of the recently proposed amino acid code for RNA recognition by PPR proteins ranks them at first and second positions of the most probable targets.
Journal: Mitochondrion - Volume 19, Part B, November 2014, Pages 126–134