کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2068998 1078370 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reversible regulation of metastasis by ROS-generating mtDNA mutations
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Reversible regulation of metastasis by ROS-generating mtDNA mutations
چکیده انگلیسی

It has been controversial whether mtDNA mutations are responsible for oncogenic transformation (normal cells to develop tumors), and for malignant progression (tumor cells to develop metastases). To clarify this issue, we created trans-mitochondrial cybrids with mtDNA exchanged between mouse tumor cells that express different metastatic phenotypes. The G13997A mutation in the ND6 gene of mtDNA from high metastatic tumor cells reversibly controlled development of metastases by overproduction of reactive oxygen species (ROS), but did not control development of tumors. The mtDNA-mediated reversible control of metastasis reveals a novel function of mtDNA, and suggests that ROS scavengers may be therapeutically effective in suppressing metastasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mitochondrion - Volume 8, Issue 4, September 2008, Pages 339–344
نویسندگان
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