کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2070401 1078491 2007 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): Interaction with other regulatory ligands
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): Interaction with other regulatory ligands
چکیده انگلیسی

All members of the inwardly rectifying potassium channels (Kir1-7) are regulated by the membrane phospholipid, phosphatidylinosital-4,5-bisphosphate (PIP2). Some are also modulated by other regulatory factors or ligands such as ATP and G-proteins, which give them their common names, such as the ATP sensitive potassium (KATP) channel and the G-protein gated potassium channel. Other more non-specific regulators include polyamines, kinases, pH and Na+ ions. Recent studies have demonstrated that PIP2 acts cooperatively with other regulatory factors to modulate Kir channels. Here we review how PIP2 and co-factors modulate channel activities in each subfamily of the Kir channels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Biophysics and Molecular Biology - Volume 94, Issue 3, July 2007, Pages 320–335
نویسندگان
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