کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2070554 1078517 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functions and Roles of Proteins: Diabetes as a Paradigm
ترجمه فارسی عنوان
توابع و نقش پروتئین ها: دیابت به عنوان یک پارادایم
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
چکیده انگلیسی

Molecular and cellular biology has moved towards complete and accurate knowledge of how molecules behave in space and time. Protein is considered as the primary group of molecules responsible for mediating most physiological processes. Changes in the levels of proteins may lead to the altered function and are responsible for many diseases. This review provides a partial molecular explanation of biological force-ratio generation that may act to split protein into branches, and shows molecular functional divergence. Developing a non-reductionist theory of the cellular function in medicine is clearly not sufficient. Finding effective parameters of the models by characterizing molecular interactions becomes necessary. Protein interactivity and stability provides a basis for an integrated understanding of pathologies such diabetes. One example of how a mechanistic analysis of such physiological processes can be of value is the time-delay between mRNA and translation that can act as a fork allowing a slowdown in gene expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Biophysics and Molecular Biology - Volume 114, Issue 1, January 2014, Pages 2–7
نویسندگان
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