کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2072625 | 1544718 | 2015 | 9 صفحه PDF | دانلود رایگان |
• Important features of germ cells.
• CB proteome: evidences linking the nucleolar cycle and the CB assembling; circadian proteins found in the CB.
• CB transcriptome: miRNAs and piRNAs pathways; X chromosome but not Y chromosome transcripts enriching the CB.
Several genetic and epigenetic events that take place in the nucleus (i.e. meiotic recombination, meiotic silencing, chromatin reorganization and histone replacement) are crucial for the spermatogenesis process, as well as, is the assembling of cytoplasmic bodies (or chromatoid bodies). In this minireview, we give special attention to the most recent research approaches involved in the molecular structure and physiology of the chromatoid body (CB). Though it was described several decades ago, the CB is still a very intriguing cytoplasmic structure of male germ cells. It plays roles in the most important steps of the spermatozoon formation, such as mRNA regulation, smallRNA-mediated gene control, and cell communication among round spermatids. Studies that have been done on the CB largely focus on two main topics: (1) CB proteome, in this minireview focused on ‘Evidences linking the nucleolar cycle and the CB assembling; and Circadian proteins found in the CB’; and (2) CB transcriptome, in this minireview focused on ‘miRNAs and piRNAs pathways; and X but not Y chromosome transcripts enriching the CB’. Herein, we described the most relevant results produced in each of these subjects in order to clarify the main physiological role played by this intriguing cytoplasmic structure in the germ cells of male mammals, which though long since described, still fascinates researchers in the field.
Journal: Animal Reproduction Science - Volume 159, August 2015, Pages 8–16