کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2092227 | 1546004 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The two-component system NisK/NisR contributes to the virulence of Streptococcus suis serotype 2
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
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چکیده انگلیسی
Two-component signal-transduction systems (TCSTSs) may regulate some virulence factors in response to external stimuli, and thus allowing Streptococcus suis serotype 2 to interact with the host, promote survival, and cause disease. Here, a mutant of the NisKR TCSTS had attenuated virulence in vitro, as exemplified by lowered hemolytic activity, reduced adherence to epithelial cells, increased elimination by macrophages, and decreased resistance to killing by neutrophils. Results also showed that this system is important for the ability of S. suis serotype 2 to survive and proliferate in an in vivo mouse model. Thus, the NisKR system plays a significant role in pathogenesis, both in colonization and invasive disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbiological Research - Volume 169, Issues 7–8, July–August 2014, Pages 541–546
Journal: Microbiological Research - Volume 169, Issues 7–8, July–August 2014, Pages 541–546
نویسندگان
Juan Xu, Shulin Fu, Manli Liu, Qiaoxia Xu, Weicheng Bei, Huanchun Chen, Chen Tan,