کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2092993 1546001 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The antimicrobial peptide cathelicidin-BF could be a potential therapeutic for Salmonella typhimurium infection
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
The antimicrobial peptide cathelicidin-BF could be a potential therapeutic for Salmonella typhimurium infection
چکیده انگلیسی

Resistance is increasing to several critical antimicrobials used to treat Salmonella typhimurium infection, urging people to search for new antimicrobial agents. In this work, we reported the possibility of a potent antimicrobial peptide cathelicidin-BF found in the venom of the snake Bungarus fasciatus in treating Salmonella typhimurium infection. We tested its activity in biological fluids and in vivo using a mouse model of Salmonella typhimurium infection, and examined the effect of cathelicidin-BF on Salmonella invasion to epithelial cells. In addition, the biodistribution of cathelicidin-BF was evaluated by using in vivo optical imaging. The results revealed that cathelicidin-BF was unstable in gastrointestinal tract, but retained substantially active in murine serum. Cathelicidin-BF attenuated the clinical symptoms of Salmonella infected-mice, significantly reduced the number of internalized Salmonella and attenuated Salmonella-induced decreases in TER in epithelial cells. Our results provide a first indication for the potential of cathelicidin-BF as a novel therapeutic option for salmonellosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbiological Research - Volume 171, February 2015, Pages 45–51
نویسندگان
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