کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2100161 1082984 2009 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gene expression profiling in chronic lymphocytic leukaemia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Gene expression profiling in chronic lymphocytic leukaemia
چکیده انگلیسی

The proliferation of new techniques that allow a multiparametric study of gene expression, the mutational state of genomic DNA, DNA methylation and the phosphorylation of receptor and adaptor proteins has led to an increased understanding of the origin of different cancers, the definition of new prognosis markers and the response to treatment profiles. Gene profiling studies on chronic lymphocytic leukaemia (CLL) are at the origin of new prognosis markers such as zeta-associated protein-70 (ZAP-70), LPL and CLLU1, which, at present, are under study for their application to clinical practice. An increased resolution in the mutational state at genomic level has underscored the importance of deletion 13q14 at the origin of CLL and 13q and 17p in response to treatment. Some new insights regarding changes in gene expression in CLL cells depending on the microenvironment have been described, but more work is yet to be done in the field.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Haematology - Volume 22, Issue 2, June 2009, Pages 211–222
نویسندگان
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