کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2100401 1082999 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Infectious complications of chronic lymphocytic leukaemia: pathogenesis, spectrum of infection, preventive approaches
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Infectious complications of chronic lymphocytic leukaemia: pathogenesis, spectrum of infection, preventive approaches
چکیده انگلیسی

Infectious complications continue to be a major cause of morbidity and mortality in patients with chronic lymphocytic leukaemia (CLL). The pathogenesis of infections in these patients is multifactorial, related to inherent immune defects and therapy-related immunosuppression. Hypogammaglobulinaemia is an important predisposing factor for infection in all patients. The use of the purine analogues such as fludarabine, and monoclonal antibodies such as rituximab and alemtuzumab, has introduced a new spectrum of infectious complications caused by pathogens such as Pneumocystis, Listeria, mycobacteria, herpesviruses Candida and Aspergillus, related to the cellular immune suppression induced by these agents. This review focusses on the pathogenesis and risk factors for infections in patients with CLL, the spectrum of infectious complications and preventive approaches to infection in these patients, using antimicrobial and immunoglobulin prophylaxis and vaccination strategies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Haematology - Volume 23, Issue 1, March 2010, Pages 145–153
نویسندگان
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