کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2100448 1083001 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel BMT technique for treatment of various currently intractable diseases
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
A novel BMT technique for treatment of various currently intractable diseases
چکیده انگلیسی

A recently-developed BMT method combines a “Perfusion Method” (PM) for collecting bone marrow cells (BMCs) with the Intra-Bone Marrow (IBM) injection of BMCs (IBM-BMT). As distinct from the conventional aspiration method (AM), the PM allows rapid (within 1 h) collection of BMCs without T cell contamination (T cells < 10%). Therefore, no GvHD occurs. Moreover, the burden on donors, such as back pain, bleeding and infection, can be reduced.Full chimerism can be achieved even with only mild conditioning regimens if IBM-BMT is carried out, since IBM-BMT replaces not only the recipient’s hemopoietic stem cells (HSCs) but also mesenchymal stem cells (MSCs) with donor-derived HSCs and MSCs.Using this method, we show that most currently intractable diseases are HSC or MSC disorders, and that this novel strategy (PM + IBM−BMT) can be used to treat various otherwise intractable diseases (including autoimmune diseases and age-associated diseases).We believe that the development of this technique will herald a revolution in the field of BMT, regeneration medicine and also organ transplantation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Haematology - Volume 24, Issue 3, September 2011, Pages 477–483
نویسندگان
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