کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2100490 1083003 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Can every patient be mobilized?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Can every patient be mobilized?
چکیده انگلیسی
There are several ways to mobilize hematopoietic stem cells for autologous and allogeneic hematopoietic stem cell transplant by manipulating the bone marrow microenvironment. Granulocyte colony-stimulating factor (G-CSF) and chemotherapy have been commonly used to mobilize stem cells, but several new agents, such as the CXCR4 inhibitor plerixafor, inhibit stromal-stem cell interactions to improve stem cell yield. The minimum threshold for engraftment is 2 × 106 CD34+ cells/kg, but it has been shown that higher CD34+ stem cell dose, such as 5 × 106 CD34+ cells/kg, is associated with improved survival. Efforts to increase stem cell yield remain important to improve outcomes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Haematology - Volume 23, Issue 4, December 2010, Pages 519-523
نویسندگان
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