Antibodies: Immunoconjugates and autologous cellular therapy in acute lymphoblastic leukemia

Using a case study of a 57-year-old man with relapsed/refractory precursor-B (pre-B) acute lymphoblastic leukemia (ALL), this review discusses treatment with immunoconjugates and autologous therapy in acute ALL. Three therapies—blinatumomab, inotuzumab, and CAR T cells—are considered here, each with advantages in specific clinical situations. These therapies represent some of the exciting advances that have been made in the treatment of ALL over the last several years.