کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2100727 1083064 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thrombopoietin in normal and neoplastic stem cell development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Thrombopoietin in normal and neoplastic stem cell development
چکیده انگلیسی
It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia (c-MPL) proto-oncogene. The c-MPL receptor may also play an important role in the development of human myeloproliferative disorders, essential thrombocythemia, myelofibrosis and polycythemia vera, cooperating with the dysregulated Janus kinase JAK2V617F.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Haematology - Volume 22, Issue 4, December 2009, Pages 495-499
نویسندگان
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