LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer

• HOTAIR is a long non-coding RNA.
• HOTAIR interacts with PRC2 and LSD1 and regulates gene silencing.
• HOTAIR is overexpressed in variety of cancer.
• We reviewed the functions of HOTAIR and its regulation.
• We reviewed the associations of HOTAIR with cancer and other diseases.

Non-coding RNAs (ncRNAs) are emerging classes of regulatory RNA that play key roles in various cellular and physiological processes such as in gene regulation, chromatin dynamics, cell differentiation, and development. NcRNAs are dysregulated in a variety of human disorders including cancers, neurological disorders, and immunological disorders. The mechanisms through which ncRNAs regulate various biological processes and human diseases still remain elusive. HOX antisense intergenic RNA (HOTAIR) is a recently discovered long non-coding RNA (lncRNA) that plays critical role in gene regulation and chromatin dynamics, appears to be misregulated in a variety of cancers. HOTAIR interacts with key epigenetic regulators such as histone methyltransferase PRC2 and histone demethylase LSD1 and regulates gene silencing. Here, we have reviewed recent advancements in understanding the functions and regulation of HOTAIR and its association with cancer and other diseases.