کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2107493 1083681 2009 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma
چکیده انگلیسی

SummaryThe growth of many cancers depends on self-renewing cells called cancer stem cells or tumor-propagating cells (TPCs). In human brain tumors, cells expressing the stem cell marker CD133 have been implicated as TPCs. Here we show that tumors from a model of medulloblastoma, the Patched mutant mouse, are propagated not by CD133+ cells but by cells expressing the progenitor markers Math1 and CD15/SSEA-1. These cells have a distinct expression profile that suggests increased proliferative capacity and decreased tendency to undergo apoptosis and differentiation. CD15 is also found in a subset of human medulloblastomas, and tumors expressing genes similar to those found in murine CD15+ cells have a poorer prognosis. Thus, CD15 may represent an important marker for TPCs in medulloblastoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 15, Issue 2, 3 February 2009, Pages 135–147
نویسندگان
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