کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2107494 1083681 2009 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice
چکیده انگلیسی

SummarymTOR complex 2 (mTORC2) contains the mammalian target of rapamycin (mTOR) kinase and the Rictor regulatory protein and phosphorylates Akt. Whether this function of mTORC2 is critical for cancer progression is unknown. Here, we show that transformed human prostate epithelial cells lacking PTEN require mTORC2 to form tumors when injected into nude mice. Furthermore, we find that Rictor is a haploinsufficient gene and that deleting one copy protects Pten heterozygous mice from prostate cancer. Finally, we show that the development of prostate cancer caused by Pten deletion specifically in prostate epithelium requires mTORC2, but that for normal prostate epithelial cells, mTORC2 activity is nonessential. The selective requirement for mTORC2 in tumor development suggests that mTORC2 inhibitors may be of substantial clinical utility.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 15, Issue 2, 3 February 2009, Pages 148–159
نویسندگان
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