کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2107522 | 1083683 | 2010 | 13 صفحه PDF | دانلود رایگان |
SummaryChe-1 is a RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes p53 transcription. In this study, we investigated whether Che-1 regulates mutant p53 expression. We found that Che-1 is required for sustaining mutant p53 expression in several cancer cell lines, and that Che-1 depletion by siRNA induces apoptosis both in vitro and in vivo. Notably, loss of Che-1 activates DNA damage checkpoint response and induces transactivation of p73. Therefore, these findings underline the important role that Che-1 has in survival of cells expressing mutant p53.
► Che-1 sustains mutant p53 expression
► Inhibition of Che-1 selectively kills tumor cells carrying mutant p53
► Inhibition of Che-1 induces DNA damage in cancer cells expressing mutant p53
► These findings suggest a therapeutic approach against tumors harboring mutant p53
Journal: - Volume 18, Issue 2, 17 August 2010, Pages 122–134