کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2107526 | 1083683 | 2010 | 14 صفحه PDF | دانلود رایگان |
SummaryTwo vascular growth factor families, VEGF and the angiopoietins, play critical and coordinate roles in tumor progression and metastasis. A single inhibitor targeting both VEGF and angiopoietins is not available. Here, we developed a chimeric decoy receptor, namely double anti-angiogenic protein (DAAP), which can simultaneously bind VEGF-A and angiopoietins, blocking their actions. Compared to VEGF-Trap or Tie2-Fc, which block either VEGF-A or angiopoietins alone, we believe DAAP is a highly effective molecule for regressing tumor angiogenesis and metastasis in implanted and spontaneous solid tumors; it can also effectively reduce ascites formation and vascular leakage in an ovarian carcinoma model. Thus, simultaneous blockade of VEGF-A and angiopoietins with DAAP is an effective therapeutic strategy for blocking tumor angiogenesis, metastasis, and vascular leakage.
► DAAP simultaneously binds VEGF-A and angiopoietins, and blocks their actions
► DAAP effectively suppresses tumor angiogenesis, metastasis and vascular leakage
► DAAP is superior to VEGF-Trap plus Tie2-Fc in blocking tumor growth and metastasis
► Ang-2 is a therapeutic target to control tumor angiogenesis and vascular leakage
Journal: - Volume 18, Issue 2, 17 August 2010, Pages 171–184