FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

SummaryChronically activated leukocytes recruited to premalignant tissues functionally contribute to cancer development; however, mechanisms underlying pro- versus anti-tumor programming of neoplastic tissues by immune cells remain obscure. Using the K14-HPV16 mouse model of squamous carcinogenesis, we report that B cells and humoral immunity foster cancer development by activating Fcγ receptors (FcγRs) on resident and recruited myeloid cells. Stromal accumulation of autoantibodies in premalignant skin, through their interaction with activating FcγRs, regulate recruitment, composition, and bioeffector functions of leukocytes in neoplastic tissue, which in turn promote neoplastic progression and subsequent carcinoma development. These findings support a model in which B cells, humoral immunity, and activating FcγRs are required for establishing chronic inflammatory programs that promote de novo carcinogenesis.

► Humoral immunity regulates squamous carcinogenesis
► FcRγ activation regulates inflammation-associated squamous carcinogenesis
► Protumor activity of mast cells is FcRγ dependent
► FcRγ regulates angiogenic and protumor properties of macrophages