کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2107728 1083697 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasminogen Activator Inhibitor-1 Protects Endothelial Cells from FasL-Mediated Apoptosis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Plasminogen Activator Inhibitor-1 Protects Endothelial Cells from FasL-Mediated Apoptosis
چکیده انگلیسی

SummaryPlasminogen activator inhibitor-1 (PAI-1) paradoxically enhances tumor progression and angiogenesis; however, the mechanism supporting this role is not known. Here we provide evidence that PAI-1 is essential to protect endothelial cells (ECs) from FasL-mediated apoptosis. In the absence of host-derived PAI-1, human neuroblastoma cells implanted in PAI-1-deficient mice form smaller and poorly vascularized tumors containing an increased number of apoptotic ECs. We observed that knockdown of PAI-1 in ECs enhances cell-associated plasmin activity and increases spontaneous apoptosis in vitro. We further demonstrate that plasmin cleaves FasL at Arg144-Lys145, releasing a soluble proapoptotic FasL fragment from the surface of ECs. The data provide a mechanism explaining the proangiogenic activity of PAI-1.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 14, Issue 4, 7 October 2008, Pages 324–334
نویسندگان
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