کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2107782 1083701 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Silencing or Fueling Metastasis with VEGF Inhibitors: Antiangiogenesis Revisited
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Silencing or Fueling Metastasis with VEGF Inhibitors: Antiangiogenesis Revisited
چکیده انگلیسی

Clinical practice reveals that therapy with angiogenesis inhibitors often does not prolong survival of cancer patients for more than months, because tumors elicit evasive resistance. In this issue of Cancer Cell, two papers report that VEGF inhibitors reduce primary tumor growth but promote tumor invasiveness and metastasis. These perplexing findings help to explain resistance to these drugs but raise pertinent questions of how to best treat cancer patients with antiangiogenic medicine in the future. We discuss here how VEGF inhibitors can induce such divergent effects on primary tumor growth and metastasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 15, Issue 3, 3 March 2009, Pages 167–170
نویسندگان
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