کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2107841 | 1083705 | 2010 | 14 صفحه PDF | دانلود رایگان |
SummaryThe neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133− cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133+ and CD133− self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. Our results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-renewing cell types expressing a range of markers of forebrain lineage.
► GBM PTEN deficiency correlates with successfully expandable neurosphere culture
► Identification of self-renewing CD133− cell type generating CD133+ and CD133− progeny
► Evidence for lineage hierarchy of self-renewing, tumor-initiating cells in GBM
► GBM cell lineage with graded spectrum of cancer stem cell competencies
Journal: - Volume 17, Issue 4, 13 April 2010, Pages 362–375