کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2108082 1083720 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MicroRNA Signature Predicts Survival and Relapse in Lung Cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
MicroRNA Signature Predicts Survival and Relapse in Lung Cancer
چکیده انگلیسی

SummaryWe investigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients. Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets. Using Cox regression and risk-score analysis, we identified a five-microRNA signature for the prediction of treatment outcome of NSCLC in the training set. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk scores in their microRNA signatures had poor overall and disease-free survivals compared to the low-risk-score patients. This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 13, Issue 1, 8 January 2008, Pages 48–57
نویسندگان
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