کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2108095 | 1083721 | 2013 | 14 صفحه PDF | دانلود رایگان |

SummaryWe isolated a tumor B-cell-targeting antibody, BI-505, from a highly diversified human phage-antibody library, using a pioneering “function-first” approach involving screening for (1) specificity for a tumor B cell surface receptor, (2) induction of tumor programmed cell death, and (3) enhanced in vivo antitumor activity compared to currently used treatments. BI-505 bound to intercellular adhesion molecule-1, identifying a previously unrecognized role for this receptor as a therapeutic target in cancer. The BI-505 epitope was strongly expressed on the surface of multiple myeloma cells from both newly diagnosed and relapsed patients. BI-505 had potent macrophage-dependent antimyeloma activity and conferred enhanced survival compared to currently used treatments in advanced experimental models of multiple myeloma.
► Function-first screening method rapidly identifies antitumor antibodies
► A human anti-ICAM-1 antibody, BI-505, with therapeutic potential
► ICAM-1 is highly expressed on the surface of myeloma cells
► BI-505 has potent macrophage-dependent antimyeloma activity
Journal: - Volume 23, Issue 4, 15 April 2013, Pages 502–515