کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2108095 1083721 2013 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Human ICAM-1 Antibody Isolated by a Function-First Approach Has Potent Macrophage-Dependent Antimyeloma Activity In Vivo
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
A Human ICAM-1 Antibody Isolated by a Function-First Approach Has Potent Macrophage-Dependent Antimyeloma Activity In Vivo
چکیده انگلیسی

SummaryWe isolated a tumor B-cell-targeting antibody, BI-505, from a highly diversified human phage-antibody library, using a pioneering “function-first” approach involving screening for (1) specificity for a tumor B cell surface receptor, (2) induction of tumor programmed cell death, and (3) enhanced in vivo antitumor activity compared to currently used treatments. BI-505 bound to intercellular adhesion molecule-1, identifying a previously unrecognized role for this receptor as a therapeutic target in cancer. The BI-505 epitope was strongly expressed on the surface of multiple myeloma cells from both newly diagnosed and relapsed patients. BI-505 had potent macrophage-dependent antimyeloma activity and conferred enhanced survival compared to currently used treatments in advanced experimental models of multiple myeloma.


► Function-first screening method rapidly identifies antitumor antibodies
► A human anti-ICAM-1 antibody, BI-505, with therapeutic potential
► ICAM-1 is highly expressed on the surface of myeloma cells
► BI-505 has potent macrophage-dependent antimyeloma activity

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 23, Issue 4, 15 April 2013, Pages 502–515
نویسندگان
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