کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2108378 1083776 2009 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of Androgen Receptor Transcriptional Activity and Specificity by RNF6-Induced Ubiquitination
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Regulation of Androgen Receptor Transcriptional Activity and Specificity by RNF6-Induced Ubiquitination
چکیده انگلیسی

SummaryThe androgen receptor (AR) plays a critical role in prostate cancer. We have identified a ubiquitin E3 ligase, RNF6, as an AR-associated protein in a proteomic screen. RNF6 induces AR ubiquitination and promotes AR transcriptional activity. Specific knockdown of RNF6 or mutation of RNF6-induced ubiquitination acceptor sites on AR selectively alters expression of a subset of AR target genes and diminishes recruitment of AR and its coactivators to androgen-responsive elements present in the regulatory region of these genes. Furthermore, RNF6 is overexpressed in hormone-refractory human prostate cancer tissues and required for prostate cancer cell growth under androgen-depleted conditions. Our data suggest that RNF6-induced ubiquitination may regulate AR transcriptional activity and specificity through modulating cofactor recruitment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 15, Issue 4, 7 April 2009, Pages 270–282
نویسندگان
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