کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2108382 | 1083776 | 2009 | 13 صفحه PDF | دانلود رایگان |

SummaryGlioma-initiating cells (GICs) are responsible for the initiation and recurrence of gliomas. Here, we identify a molecular mechanism that regulates the self-renewal capacity of patient-derived GICs. We show that TGF-β and LIF induce the self-renewal capacity and prevent the differentiation of GICs. TGF-β induces the self-renewal capacity of GICs, but not of normal human neuroprogenitors, through the Smad-dependent induction of LIF and the subsequent activation of the JAK-STAT pathway. The effect of TGF-β and LIF on GICs promotes oncogenesis in vivo. Some human gliomas express high levels of LIF that correlate with high expression of TGF-β2 and neuroprogenitor cell markers. Our results show that TGF-β and LIF have an essential role in the regulation of GICs in human glioblastoma.
Journal: - Volume 15, Issue 4, 7 April 2009, Pages 315–327