کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2109487 1083877 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Age differences in presentation, diagnosis pathway and management of colorectal cancer
ترجمه فارسی عنوان
تفاوت سن در ارائه، مسیر تشخیص و مدیریت سرطان کولورکتال
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


• We explored age disparities with respect to the diagnosis and treatment of colorectal cancer patients.
• No longer duration to diagnosis or treatment was observed in the oldest groups.
• Quality indicators during the diagnostic process are equally distributed between age groups.
• We found less chemotherapy as well as radiotherapy as age increases.

BackgroundThe gap in survival between older and younger European cancer patients is getting wider. It is possible that cancer in the elderly is being managed or treated differently than in their younger counterparts. This study aims to explore age disparities with respect to the clinical characteristics of the tumour, diagnostic pathway and treatment of colorectal cancer patients.MethodsWe conducted a multicenter cross sectional study in 5 Spanish regions. Consecutive incident cases of CRC were identified from pathology services. Measurements: From patient interviews, hospital and primary care clinical records, we collected data on symptoms, stage, doctors investigations, time duration to diagnosis/treatment, quality of care and treatment.Results777 symptomatic cases, 154 were older than 80 years. Stage was similar by age group. General symptoms were more frequent in the eldest and abdominal symptoms in the youngest. No differences were found regarding perception of symptom seriousness and symptom disclosure between age groups as no longer duration to diagnosis or treatment was observed in the oldest groups. In primary care, only ultrasound is more frequently ordered in those <65 years. Those >80 years had a significantly higher proportion of iron testing and abdominal XR requested in hospital. We observed a high resection rate independently of age but less adjuvant chemotherapy in Stage III colon cancer, and of radiotherapy in stage II and III rectal cancer as age increases.ConclusionThere are no relevant age disparities in the CRC diagnosis process with similar stage, duration to diagnosis, investigations and surgery. However, further improvements have to be made with respect to adjuvant therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Epidemiology - Volume 38, Issue 4, August 2014, Pages 346–353
نویسندگان
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