کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2109938 | 1083900 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Unbalanced 11;18 translocation in an acute erythroid leukemia after radioactive iodine therapy
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Therapy-related acute myeloid leukemia (t-AML) is well described after chemotherapy or radiotherapy for diverse malignancies. Radioisotope therapy is also recognized as a less-common cause of t-AML. We describe a patient with acute erythroid leukemia after radioactive iodine administration for papillary thyroid cancer, with an unbalanced 11;18 translocation resulting in three copies of 11q, including the MLL gene. Although an increased incidence of chronic myeloid leukemia has been documented after radioactive iodine exposure, acute leukemia in this setting has been less frequently seen. Moreover, to our knowledge, the chromosome abnormality present in our patient has not been previously reported. The literature on cytogenetic abnormalities in t-AML after radioactive iodine administration is reviewed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Genetics - Volume 206, Issue 6, June 2013, Pages 252-255
Journal: Cancer Genetics - Volume 206, Issue 6, June 2013, Pages 252-255
نویسندگان
Nikolaos A. Trikalinos, Qing Chen, Yi Ning, Edward A. Sausville, Maria R. Baer,