کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2110104 1546559 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
When are apparently non-clonal abnormalities in bone marrow chromosome studies actually clonal?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
When are apparently non-clonal abnormalities in bone marrow chromosome studies actually clonal?
چکیده انگلیسی

The observation of an apparently non-clonal abnormal cell in a cytogenetic study for a hematologic neoplasm opens the possibility of a small, or slowly proliferating, abnormal clone. Many laboratories analyze additional cells or reflex to fluorescence in situ hybridization (FISH) to evaluate this possibility further. In a retrospective study of 500 cases with a non-clonal abnormal cell identified in a 20-cell analysis, we found that the benefit of additional metaphase analysis was limited to specific categories of abnormal karyotypes, including those with a complex karyotype or a classic abnormality known to be a recurring finding in hematologic neoplasms, and excluding all other categories.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Genetics - Volume 205, Issues 7–8, July–August 2012, Pages 405–409
نویسندگان
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