کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2110314 1083924 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tumor heterogeneity uncovered by dynamic expression of long noncoding RNA at single-cell resolution
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Tumor heterogeneity uncovered by dynamic expression of long noncoding RNA at single-cell resolution
چکیده انگلیسی

The expression of long noncoding RNA (lncRNA) is thought to be more cell-type specific than the expression of protein-coding genes. However, the expression profile of individual cells regarding lncRNA remains to be elucidated. Here, we comprehensively investigated the pattern of lncRNA expression across five glioblastoma tumors (414 cells) and two cell lines (GBM6 and GBM8, 127 cells). We found that there were more than 1,000 lncRNAs that varied between any two cells and that there was frequent gain and loss of lncRNA expression during tumor cell proliferation, suggesting a great heterogeneity in lncRNA expression across different single cells in glioblastoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Genetics - Volume 208, Issue 12, December 2015, Pages 581–586
نویسندگان
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