کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2110350 1546554 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ewing sarcoma mimicking atypical carcinoid tumor: detection of unexpected genomic alterations demonstrates the use of next generation sequencing as a diagnostic tool
ترجمه فارسی عنوان
سارکوما یوینگ، تقلید تومور کارسینوئید آتیپیک: تشخیص تغییرات ژنتیکی غیر منتظره نشان می دهد که استفاده از ترتیب نسل بعدی به عنوان یک ابزار تشخیصی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

Increasingly, tumors are being analyzed for a variety of mutations and other genomic changes, with the goals of guiding personalized therapy and directing patients to appropriate clinical trials based on genotype, as well as identifying previously unknown genomic changes in different tumor types and thereby providing new insights into the pathogenesis of human cancers. Next generation sequencing is a powerful research tool now gaining traction in the clinic. In this report, we demonstrate the utility of next generation sequencing assays in providing diagnostic information when evaluating tumor specimens. This is illustrated by a case previously thought to represent an atypical carcinoid tumor, in which an EWSR1-ERG translocation was detected during next generation sequencing using a hybrid capture approach, leading to a revised diagnosis of Ewing sarcoma. The role of translocation detection in these assays is also discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Genetics - Volume 207, Issues 7–8, July–August 2014, Pages 335–339
نویسندگان
, , , , , , ,