کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2110479 1083935 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A possible 5′-NRIP1/UHRF1-3′ fusion gene detected by array CGH analysis in a Ph+ ALL patient
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
A possible 5′-NRIP1/UHRF1-3′ fusion gene detected by array CGH analysis in a Ph+ ALL patient
چکیده انگلیسی

A translocation between chromosomes 19 and 21 [dic/t(19;21)(p13;v)] is very rare. To date, only three cases of this particular chromosomal abnormality have been reported. The translocations in these three cases were secondary changes in acute lymphoblastic leukemia (ALL) patients with the t(9;22) translocation. The gene(s) at the breakpoints of either chromosome 19p13 or 21q have not yet been identified. Here, we present a case study of a 21-year-old female with a diagnosis of precursor B cell ALL, with the t(9;22) translocation and secondary changes including a der(19)t(19;21) and an extra Philadelphia (Ph+) chromosome [der(22)t(9;22)]. Array comparative genomic hybridization (aCGH) analysis identified UHRF1 and NRIP1 as genes that were interrupted at the breakpoints of 19p13.3 and 21q21.1, and joined together as a possible fusion gene, 5′-NRIP1/UHRF1-3′, on the derivative chromosome 19. To our knowledge, this is the first description of possible genes involved in the unbalanced translocation between chromosomes 19 and 21 in a patient with an ALL-positive for a t(9;22) translocation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Genetics - Volume 204, Issue 12, December 2011, Pages 687–691
نویسندگان
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