کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2110534 1083938 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Jumping translocation of chromosome 1q associated with good clinical outcome in a case of Burkitt leukemia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Jumping translocation of chromosome 1q associated with good clinical outcome in a case of Burkitt leukemia
چکیده انگلیسی

Acquired jumping translocations (JTs) are rare secondary aberrations occurring in various hematological malignancies. In Burkitt lymphoma/leukemia (BL) chromosome 1q abnormalities such as partial or whole arm duplications/translocations are frequently associated with the disease-specific t(8;14)(q24;q32). JTs of 1q are considered to have a bad prognostic impact in BL. We report clinical, conventional and molecular cytogenetic findings of a 12-year-old boy who presented with BL. In addition to the primary aberration, t(8;14)(q24;q32), JT of 1q onto chromosomes 21 and der(14) as well as the formation of isochromosome 1q could be detected in his bone marrow sample. Despite the expected poor prognostic outcome of these aberrations, the patient has been experiencing an event free survival of 7.5 years at the time of the present report, reflecting the excellent clinical outcome of the disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Genetics - Volume 204, Issue 4, April 2011, Pages 207–210
نویسندگان
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