کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2110567 1546574 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
FISH-negative cryptic PML–RARA rearrangement detected by long-distance polymerase chain reaction and sequencing analyses: a case study and review of the literature
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
FISH-negative cryptic PML–RARA rearrangement detected by long-distance polymerase chain reaction and sequencing analyses: a case study and review of the literature
چکیده انگلیسی

Although a normal karyotype according to conventional cytogenetic analysis in association with cryptic t(15;17) has been infrequently reported in cases of acute promyelocytic leukemia (APL), a fluorescence in situ hybridization (FISH)-negative cryptic PML–RARA rearrangement is even more rare, with only 12 such APL cases of FISH-negative cryptic PML–RARA rearrangements in the literature. Reported here is an additional clinical APL case with a FISH-negative cryptic PML–RARA rearrangement, confirmed by long-distance DNA polymerase chain reaction method. Discussion includes a relevant literature review of similar cases. DNA-PCR can be a useful tool for the analysis of complex and cryptic rearrangements.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Genetics and Cytogenetics - Volume 203, Issue 2, December 2010, Pages 278–283
نویسندگان
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