کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2110943 | 1083953 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CTLA4 gene variations and haplotypes in patients with lung cancer
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
The CTLA4 protein downmodulates and terminates immune responses by sending inhibitory signals to activated T cells. In this study, six main single-nucleotide polymorphisms of the CTLA4 gene were investigated in 127 lung cancer patients and 124 healthy control subjects: −1722 T/C, −1661 A/G, −318 C/T, +49A/G, +1822 C/T, and +6230 A/G (CT60). Statistical analyses revealed no significant differences in the frequencies of genotypes, alleles, and haplotypes between patients and control subjects. We also could not find significant association between CTLA4 variants and any defined lung tumor type. These six single-nucleotide polymorphisms in CTLA4 were not associated with susceptibility to lung cancer in Iranian population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Genetics and Cytogenetics - Volume 196, Issue 2, 15 January 2010, Pages 171–174
Journal: Cancer Genetics and Cytogenetics - Volume 196, Issue 2, 15 January 2010, Pages 171–174
نویسندگان
Narges Khaghanzadeh, Nasrollah Erfani, Mohammad Ali Ghayumi, Abbas Ghaderi,