کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2112413 | 1084382 | 2015 | 8 صفحه PDF | دانلود رایگان |
• Autocrine hGH promotes cancer stem cell (CSC)-like properties of estrogen receptor negative mammary carcinoma (ER-MC) cells.
• Autocrine hGH increases the tumor initiating capacity of ER-MC cells.
• Autocrine hGH promotes migration and invasion of ER-MC cells in vitro, and metastasis in vivo.
The oncogenic effects of autocrine human growth hormone (hGH) have been intensively investigated in estrogen receptor-positive mammary carcinoma (ER + MC) cells. We demonstrated herein that autocrine hGH promoted cancer stem cell (CSC)-like properties of estrogen receptor-negative mammary carcinoma (ER-MC) cells in vitro. In xenograft studies, autocrine hGH increased the tumor initiating capacity of ER-MC cells. We also observed that autocrine hGH promoted migration and invasion of ER-MC cells in vitro, and metastasis in vivo. Thus, inhibition of hGH is a potential therapeutic strategy to prevent tumor initiation and metastasis of ER-MC.
Journal: Cancer Letters - Volume 365, Issue 2, 1 September 2015, Pages 182–189