کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2112543 1084395 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High dose bystander effects in spatially fractionated radiation therapy
ترجمه فارسی عنوان
اثرات متقابل دوز بالا در پرتودرمانی فشرده شده فضایی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

Traditional radiotherapy of bulky tumors has certain limitations. Spatially fractionated radiation therapy (GRID) and intensity modulated radiotherapy (IMRT) are examples of advanced modulated beam therapies that help in significant reductions in normal tissue damage. GRID refers to the delivery of a single high dose of radiation to a large treatment area that is divided into several smaller fields, while IMRT allows improved dose conformity to the tumor target compared to conventional three-dimensional conformal radiotherapy. In this review, we consider spatially fractionated radiotherapy approaches focusing on GRID and IMRT, and present complementary evidence from different studies which support the role of radiation induced signaling effects in the overall radiobiological rationale for these treatments.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 356, Issue 1, 1 January 2015, Pages 52–57
نویسندگان
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