کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2112551 1084395 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Radiation-induced bystander effect: Early process and rapid assessment
ترجمه فارسی عنوان
اثر مواجهه ناشی از تابش: روند اولیه و ارزیابی سریع
کلمات کلیدی
اثر مواجهه ناشی از اشعه، ارزیابی سریع، روند اولیه
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


• Introduce fast detection methods to assess radiation-induced bystander effect (RIBE).
• Evidences show the existence of initiation and early process of RIBE.
• Discuss the mechanisms of early process of RIBE.

Radiation-induced bystander effect (RIBE) is a biological process that has received attention over the past two decades. RIBE refers to a plethora of biological effects in non-irradiated cells, including induction of genetic damages, gene expression, cell transformation, proliferation and cell death, which are initiated by receiving bystander signals released from irradiated cells. RIBE brings potential hazards to normal tissues in radiotherapy, and imparts a higher risk from low-dose radiation than we previously thought. Detection with proteins related to DNA damage and repair, cell cycle control, proliferation, etc. have enabled rapid assessment of RIBE in a number of research systems such as cultured cells, three-dimensional tissue models and animal models. Accumulated experimental data have suggested that RIBE may be initiated rapidly within a time frame as short as several minutes after radiation. These have led to the requirement of techniques capable of rapidly assessing RIBE itself as well as assessing the early processes involved.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 356, Issue 1, 1 January 2015, Pages 137–144
نویسندگان
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