کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2112602 1084402 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
β6 integrin induces the expression of metalloproteinase-3 and metalloproteinase-9 in colon cancer cells via ERK-ETS1 pathway
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
β6 integrin induces the expression of metalloproteinase-3 and metalloproteinase-9 in colon cancer cells via ERK-ETS1 pathway
چکیده انگلیسی


• β6 integrin induces ETS1 activation via the ERK/MAPK pathways.
• ETS1 regulates MMP-3/MMP-9 gene expression in colon cancer cells.
• β6 integrin up-regulates MMP-3/MMP-9 by ERK-ETS1 signaling pathways.
• Internalization of integrin αvβ6 plays a role in β6-induced ETS1 activities.
• β6-induced MMP-3/MMP-9 via ERK-ETS1 is required for invasion of colon cancer cells.

We previously reported that β6 integrin played an important role in the progression of colon cancer. In this study, we demonstrated that β6 integrin induced the expression of MMP-3/MMP-9 and the invasion of colon cancer cells. Moreover, that function was abolished by the inhibition of ERK/MAPK pathways or knockdown of ETS1, an important transcription factor of MMP genes. Here, we showed that β6 induced phosphorylation of ETS1 via the ERK/MAPK pathways, through which the MMP-3/MMP-9 promoters were stimulated, thereby leading to the up-regulation of MMP-3/MMP-9, and subsequent the invasion of colon cancer cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 354, Issue 2, 28 November 2014, Pages 427–437
نویسندگان
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