کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2112728 1084418 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The relevance of the TGF-β Paradox to EMT-MET programs
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
The relevance of the TGF-β Paradox to EMT-MET programs
چکیده انگلیسی

The role of transforming growth factor-β (TGF-β) during tumorigenesis is complex and paradoxical, reflecting its ability to function as a tumor suppressor in normal and early-stage cancers, and as a tumor promoter in their late-stage counterparts. The switch in TGF-β function is known as the “TGF-β Paradox,” whose manifestations are intimately linked to the initiation of epithelial-mesenchymal transition (EMT) programs in developing and progressing carcinomas. Indeed, as carcinoma cells emerge from EMT programs stimulated by TGF-β, they readily display a variety of acquired phenotypes that provide a selective advantage to growing carcinomas, including (i) enhanced cell migration and invasion; (ii) heightened resistance to cytotoxic agents, targeted chemotherapeutic, and radiation treatments; and (iv) boosted expansion of cancer-initiating and stem-like cell populations that underlie tumor metastasis and disease recurrence. At present, the molecular, cellular, and microenvironmental mechanisms that enable post-EMT and metastatic carcinoma cells to hijack the oncogenic activities of TGF-β remain incompletely understood. Additionally, the molecular mechanisms that counter EMT programs and limit the aggressiveness of late-stage carcinomas, events that transpire via mesenchymal-epithelial transition (MET) reactions, also need to be further elucidated. Here we review recent advances that provide new insights into how TGF-β promotes EMT programs in late-stage carcinoma cells, as well as how these events are balanced by MET programs during the development and metastatic progression of human carcinomas.


• Mechanisms of the TGF-β Paradox.
• EMT:MET cycles in generating cancer initiating cells.
• Role of EMT:MET programs in metastatic progression.
• EMT programs and the acquisition of chemoresistance.
• Mechanisms of oncogenic TGF-β signaling.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 341, Issue 1, 28 November 2013, Pages 30–40
نویسندگان
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