کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2112806 1084425 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21waf1/cip1 and by inhibiting mutant p53
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21waf1/cip1 and by inhibiting mutant p53
چکیده انگلیسی


• Enhancer of zeste homolog 2 (EZH2) is abnormally elevated in ovarian cancer.
• EZH2 knockdown inhibited cell proliferation, colony formation, and cell invasion.
• EZH2 knockdown increased the apoptotic pathway and p21waf1/cip1 expression.
• Silencing of EZH2 inhibited mutant p53 protein and tumor xenograft growth.

The enhancer of zeste homolog 2 (EZH2) methyltransferase is a transcriptional repressor. EZH2 is abnormally elevated in epithelial ovarian cancer (EOC). We demonstrated that EZH2 knockdown inhibited cell growth, activated apoptosis, and enhanced chemosensitivity. Further, silencing of EZH2 resulted in re-expression of p21waf1/cip1 and down-regulation of mutant p53. Finally, EZH2 knockdown contributed to attenuated EOC growth in SCID mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 336, Issue 1, 9 August 2013, Pages 53–60
نویسندگان
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