کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2112880 | 1084428 | 2013 | 5 صفحه PDF | دانلود رایگان |
We investigated whether statin use is associated with reduced risk of recurrence in prostate cancer patients who undergo radiotherapy. A retrospective cohort of 774 patients from a California health plan was followed for 5 years. Statin use prior to, during and after radiotherapy was not associated with prostate cancer recurrence [hazard ratio = 0.99 (0.70–1.39), 0.87 (0.62–1.22) and 0.78 (0.55–1.09), respectively] in multivariable Cox models. No clear dose–response relationship was observed for average daily statin dose or duration of statin use. Our findings do not support a preventive benefit of statins in prostate cancer recurrence after radiotherapy.
► A total of 774 prostate cancer patients treated with radiation therapy were included in the study.
► Associations between statin use and prostate cancer recurrence after therapy were examined.
► Statin use prior to, during or after radiation therapy was not associated with risk of recurrence.
► No clear dose-response by cumulative statin dose or duration of statin use was observed.
► Findings do not support a preventive benefit of statins in prostate cancer recurrence.
Journal: Cancer Letters - Volume 335, Issue 1, 10 July 2013, Pages 214–218