کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2112963 | 1084431 | 2013 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Targeting the ceramide system in cancer Targeting the ceramide system in cancer](/preview/png/2112963.png)
Sphingolipids, in particular ceramide, have been described as important components of cellular signalling pathways. Ceramide can be produced via multiple mechanisms including through the hydrolysis of sphingomyelin by acid and neutral sphingomyelinase or by a de novo synthesis pathway. Recent studies have identified sphingomyelinases and ceramide synthases as important targets for γ-irradiation and chemotherapeutic drugs. Likewise, common cancer treatment modalities, such as γ-irradiation and many chemotherapeutic agents, induce cell death via the generation of ceramide. This suggests that the manipulation of ceramide production and metabolism could offer promising means for the enhancement of anti-tumor therapies. The focus of this mini-review will be to discuss contemporary evidence suggesting that ceramide forming pathways and ceramide itself are important targets for the treatment of tumors and the development of novel tumor treatment strategies.
• Ceramide alters membrane structures.
• Ceramide-enriched membrane platforms facilitate signalling into cells.
• Ceramide is involved in stress-induced cell death.
• Ceramide is induced by radiation- and chemotherapy and mediates tumor cell death.
• Many drugs target the ceramide system.
Journal: Cancer Letters - Volume 332, Issue 2, 28 May 2013, Pages 286–294