کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2113064 1084439 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human osteopontin splicing isoforms: Known roles, potential clinical applications and activated signaling pathways
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Human osteopontin splicing isoforms: Known roles, potential clinical applications and activated signaling pathways
چکیده انگلیسی

Human osteopontin is subject to alternative splicing, which generates three isoforms, termed OPNa, OPNb and OPNc. These variants show specific expression and roles in different cell contexts. We present an overview of current knowledge of the expression profile of human OPN splicing isoforms (OPN-SIs), their tissue-specific roles, and the pathways mediating their functional properties in different pathophysiological conditions. We also describe their putative application as biomarkers, and their potential use as therapeutic targets by using antibodies, oligonucleotides or siRNA molecules. This synthesis provides new clues for a better understanding of human OPN splice variants, their roles in normal and pathological conditions, and their possible clinical applications.


► Human OPN splice variants show specific expression and roles in different cell contexts.
► Specifc signaling pathways and cell receptors modulate the roles of OPN splicing isoforms.
► OPN splicing isoforms have potential biomarker and therapeutic applications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 331, Issue 1, 30 April 2013, Pages 11–17
نویسندگان
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