کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2113091 1546692 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kindlin-2 promotes genome instability in breast cancer cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Kindlin-2 promotes genome instability in breast cancer cells
چکیده انگلیسی

Kindlin-2, as a focal adhesion protein, has been found to regulate tumor progression. However, the mechanism underlying Kindlin-2 regulation of tumor progression is largely unknown. Here, we report that Kindlin-2 regulates breast cancer cell proliferation, apoptosis and chromosomal abnormalities in both gain and loss of function assays. Functionally, overexpression of Kindlin-2 promotes tumor formation in implanted xenograft while knockdown of Kindlin-2 inhibits tumor growth in mice. Mechanistically, an array-based comparative genomic hybridization and karyotype analyses indicate that ectopic expression of Kindlin-2 leads to genome instability in breast cancer cells. Our data suggest a novel mechanism that Kindlin-2 regulates breast cancer progression by inducing genome instability.


► Kindlin-2 promotes tumor growth in breast cancer cells.
► Kindlin-2 prevents apoptosis in breast cancer cells.
► Ectopic expression of Kindlin-2 leads to genome instability in breast cancer cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 330, Issue 2, 28 April 2013, Pages 208–216
نویسندگان
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