کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113095 | 1546692 | 2013 | 9 صفحه PDF | دانلود رایگان |
The anti-tumor activity, metronomic chemotherapy sensitization potential and metastatic effects of the endogenous angiogenesis inhibitors thrombospondin-1 and PEDF were investigated in KM12 colon adenocarcinoma xenografts. Thrombospondin-1 and PEDF decreased KM12 tumor microvessel density, increased macrophage infiltration, and improved responsiveness to metronomic cyclophosphamide (CPA) treatment, but did not activate the anti-tumor innate immunity that metronomic CPA induces in other tumor models. Moreover, thrombospondin-1, but not PEDF, significantly increased KM12 metastasis to the lung, while PEDF augmented the anti-metastatic activity of metronomic CPA. Thus, while thrombospondin-1 and PEDF both increase the KM12 tumor responsiveness to metronomic CPA, they have disparate effects on tumor metastasis.
► TSP1 and PEDF increase responsiveness of colon tumor xenografts to metronomic CPA.
► TSP1 and PEDF promote macrophage recruitment by KM12 colon tumor xenografts.
► Natural killer cell recruitment is not enhanced by TSP1 or PEDF.
► TSP1 and PEDF have disparate effects on KM12 colon tumor metastasis.
Journal: Cancer Letters - Volume 330, Issue 2, 28 April 2013, Pages 241–249