کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2113367 | 1084463 | 2012 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer](/preview/png/2113367.png)
Recent studies demonstrated that in several human malignancies aberrant expression profiles of circulating microRNAs (miRNAs) anticipate great cancer diagnostic potential. Here we showed that serum miR-378 could serve as a novel noninvasive biomarker in gastric cancer (GC) detection. Genome-wide miRNA expression profiles followed with Real-Time quantitative RT-PCR (qRT-PCR) assays revealed that miR-187*, miR-371-5p and miR-378 were significantly elevated in GC patients. Further validation indicated that miR-378 alone could yields a ROC curve area of 0.861 with 87.5% sensitivity and 70.73% specificity in discriminating GC patients from healthy controls. Collectively, these data support our contention that serum miR-378 has strong potential as a novel noninvasive biomarker in gastric cancer detection.
Journal: Cancer Letters - Volume 316, Issue 2, 28 March 2012, Pages 196–203