کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113435 | 1084467 | 2012 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Seeking to improve ovarian cancer therapy, we compared biological characteristics of the moderately-aggressive OVCAR-3 cell line with two highly aggressive ovarian cancer cell populations: the SK-OV-3 cell line, and HASCJ primary cells isolated from the ascitic fluid of a patient with FIGO stage IV ovarian cancer. Secretion of angiogenic factors was not discriminative, whereas cell invasion through Matrigel and vasculogenic mimicry were much greater in the more aggressive cells. Among 10 agents tested for their ability to decrease cancer cell aggressivity using these two models, inhibitors of Stat3, IGF-IR and Rho GTPase were found to be the most promising.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 317, Issue 2, 28 April 2012, Pages 207–217
Journal: Cancer Letters - Volume 317, Issue 2, 28 April 2012, Pages 207–217
نویسندگان
Caroline Gest, Pezhman Mirshahi, Hong Li, Linda-Louise Pritchard, Ulrich Joimel, Emmanuel Blot, Jean Chidiac, Bernard Poletto, Jean-Pierre Vannier, Remi Varin, Massoud Mirshahi, Lionel Cazin, Eric Pujade-Lauraine, Jeannette Soria, Claudine Soria,