کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2113463 | 1084470 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer](/preview/png/2113463.png)
Neural stem cells (NSCs) led to the development of a novel strategy for delivering therapeutic genes to tumors. NSCs expressing rabbit carboxyl esterase (F3.CE), which activates CPT-11, significantly inhibited the growth of MDA-MB-435 cells in the presence of CPT-11. F3.CE cells migrated selectively into the brain metastases located in the opposite hemisphere. The treatment also significantly decreased tumor volume in immune-deficient mice bearing MDA-MB-435 tumors when F3.CE cells were transplanted into the contralateral hemisphere. The survival rate was significantly prolonged with the treatment with F3.CE and CPT-11. This strategy may be considered as an effective treatment regimen for brain metastases.
► Human neural stem cells (NSCs) delivering therapeutic gene is used to treat brain metastasis of breast cancer.
► NSCs expressing a suicide gene carboxyl esterase migrated selectively into the brain tumor mass and killed tumor cells.
► The treatment significantly decreased tumor volume in brain metastasis of breast cancer, and prolonged animal survival.
► This stem cell-based suicide gene therapy could serve as an effective treatment for brain metastases of breast cancer.
Journal: Cancer Letters - Volume 311, Issue 2, 8 December 2011, Pages 152–159