کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2113484 | 1084471 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: 70-Gene classifier for differentiation between paclitaxel- and docetaxel-sensitive breast cancers 70-Gene classifier for differentiation between paclitaxel- and docetaxel-sensitive breast cancers](/preview/png/2113484.png)
Association of estrogen receptor (ER), progesterone receptor (PR), HER2, Ki67 and 70-gene classifier (70-GC) with a response to paclitaxel (PAC) (n = 79) or docetaxel (DOC) (n = 55) was investigated in the neoadjuvant setting for breast cancer patients. Sensitivity of breast tumors to PAC, but not to DOC, was found to be significantly associated with ER negativity (P = 0.003), PR negativity (P = 0.007), and Ki67 positivity (P = 0.007). Breast tumors classified into the responders by 70-GC showed a significantly (P = 0.005) higher reduction rate to PAC and interestingly a significantly (P = 0.009) lower reduction rate to DOC than those classified into the non-responders by 70-GC, suggesting that 70-GC might be useful for the differentiation of PAC-sensitive and DOC-sensitive breast tumors.
Journal: Cancer Letters - Volume 314, Issue 2, 28 January 2012, Pages 206–212